Lead program IOS-1002

The Company´s lead program IOS-1002 (formerly iosH2) is a potent LILRB and KIR-modulating agent with potential in multiple solid and liquid tumor indications. It is designed as a potential first-line monotherapy and as a combination therapy to improve medical outcomes in non-responders to adaptive immunity agents. IOS-1002 differentiates from competitor approaches as it targets multiple LILRB receptors and a KIR receptor instead of a single receptor.

In various animal models, the compound has led to tumor shrinkage (up to 90%) and to improved survival. 

The compound is expected to enter clinical trials in 2022. A Phase 1a/1b trial will be designed to deliver proof-of-concept in a monotherapy trial of IOS-1002 with an expansion cohort option for combination with anti-PD1 treatment (pembrolizumab). 

The Company also explores the combination of its products with diverse types of complementary cancer therapies, such as chemotherapy, vaccines, etc.