The Company’s multi-targeting approach is remodeling the tumor microenvironment (TME) – a key prerequisite for immunotherapy to work. This remodeling of the TME occurs in different ways:
As a result, the Company´s molecules are suited as a monotherapy or in combination therapy to make the environment more amenable to immunotherapy and have demonstrated strong anti-tumor responses in multiple cancer indications in combination with checkpoint inhibitors such as CTLA-4, PD-1, PD-L1, CD47, SIRPα and agonist antibodies such as 4-1BB.
ImmunOs Therapeutics believes that its novel family class of immunomodulators, which stimulate the immune system and increase the efficacy of both checkpoint inhibitors (CTLA-4, PD-1, PD-L1, CD47, SIRPα) and co-stimulatory agonists (e.g. 4-1BB) in combination therapies will spearhead the next wave of personalized treatments to support patients with a diverse set of cancer indications.